A Perioperative Smoking Cessation Intervention with Varenicline: A Double-blind, Randomized, Placebo-controlled Trial

Jean Wong, M.D., F.R.C.P.C.; Amir Abrishami, M.D.; Yiliang Yang, M.D.; Amna Zaki, M.B.B.S.; Zeev Friedman, M.D., F.R.C.P.C.; Peter Selby, M.B.B.S., C.C.F.P., F.C.F.P.; Kenneth R. Chapman, M.D., M.Sc., F.R.C.P.C.; Frances Chung, M.B.B.S., F.R.C.P.C.

The efficacy of perioperative tobacco interventions on long-term abstinence and the safety of smoking cessation less than 4 weeks before surgery is unclear. Our objective was to determine the efficacy and safety of a perioperative smoking cessation intervention with varenicline to reduce smoking in elective surgical patients.

A perioperative smoking cessation intervention with varenicline increased abstinence from smoking 3, 6, and 12 months after elective noncardiac surgery with no increase in serious adverse events.

Resource Link: https://pubs.asahq.org/anesthesiology/article/117/4/755/13368/A-Perioperative-Smoking-Cessation-Intervention

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